“
“OBJECTIVE: The aim of this study was to evaluate the prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation (AF).

METHODS: A cohort of 136 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy controls were enrolled. The coding exons and splice junctions of the Nkx2.5 gene were sequenced in 136 atrial fibrillation patients, and the available relatives of mutation carriers and 200 controls were subsequently selleck products genotyped for the

identified mutations. The functional characteristics of the mutated Nkx2.5 gene were analyzed using a dual-luciferase reporter assay system.

RESULTS: Two novel heterozygous Nkx2.5 mutations (p.N19D and p.F186S) were identified in 2 of the 136 unrelated atrial fibrillation cases, with a mutational prevalence of approximately 1.47%. These missense mutations co-segregated with atrial fibrillation in the families and were absent in the 400 control chromosomes. Notably, 2 mutation Selleckchem Combretastatin A4 carriers

also had congenital atrial septal defects and atrioventricular block. Multiple alignments of the Nkx2.5 protein sequences across various species revealed that the altered amino acids were completely conserved evolutionarily. Functional analysis demonstrated that the mutant Nkx2.5 proteins were associated with significantly reduced transcriptional activity compared to their wild-type counterpart.

CONCLUSION: These findings associate the Nkx2.5 loss-of-function mutation

with atrial fibrillation and atrioventricular block and provide novel insights into the molecular mechanism involved in the pathogenesis of atrial fibrillation. These results also have potential implications for early prophylaxis and allele-specific therapy of this common arrhythmia.”
“A method is described for the construction of a highly sensitive amperometric sensor for the detection of tyrosine, employing a magnetic nanoparticles-zinc oxide/zinc hexacyanoferrate (Fe3O4NP-ZnO/ZnHCF) hybrid film electrodeposited on the surface of a Pt electrode as working electrode. The sensor is based on electrocatalytic mechanism initiated by electrochemical oxidation of the reduced form of the hybrid film at +0.2 V vs. Ag/AgCl followed by completion of Sapanisertib supplier chemical oxidation of tyrosine. The sensor showed optimum response within 2 s at pH 2. The working/linear range of the sensor was 0.02-2.76 mM with a detection limit of 4 mu M. The sensor measured tyrosine level in serum, a potential biomarker of phenylketonuria. The working electrode lost only 5 % of its initial activity, when stored at 4 A degrees C, after its regular use over a period of 100 days.”
“Clinical guidelines for obstetrical practice were first published by the Japan Society of Obstetrics and Gynecology (JSOG) and the Japan Association of Obstetricians and Gynecologists (JAOG) in 2008, and a revised version was published in 2011.

FMD values were 2.3% higher after HT compared with LT (p < 0.001) after adjustment for age, gender and diet order. a-tocopherol increased significantly (p < 0.05) and hs-CRP and of gamma-glutamyltranspeptidase decreased significantly (p < 0.05 and p < 0.01, respectively) during the HT diet, compared with the LT diet.

Conclusions: A short-term HT diet improves endothelial function in volunteers at low cardiovascular risk, which may further reduce their risk of CVD. (C) 2010 Elsevier B. V. All rights reserved.”
“Multi-MeV beams of light ions have been produced using the 300 picosecond, kJ-class iodine laser, operating at the Prague Asterix Laser System facility in Prague. Real-time ion diagnostics have

been performed by the Cyclosporin A ic50 use of various time-of-flight (TOF) detectors: ion collectors (ICs) with and without absorber thin films, new prototypes of single-crystal diamond and silicon carbide detectors, and an electrostatic ion mass spectrometer (IEA). In order to suppress the long photopeak induced by soft X-rays and to avoid the overlap with the signal from ultrafast particles, the ICs have been shielded with

Al foil filters. The application of large-bandgap click here semiconductor detectors (>3 eV) ensured cutting of the plasma-emitted visible and soft-UV radiation and enhancing the sensitivity to the very fast proton/ion beams. Employing the IEA spectrometer, various ion species and charge states in the expanding laser-plasma have been determined. Processing of the experimental data based on the TOF technique, including estimation of the plasma

fast proton maximum and peak energy, ion beam currents and total charge, total number of fast protons, as well as deconvolution processes, ion stopping power, and ion/photon transmission calculations for the different metallic filters used, are reported. (C) 2011 see more American Institute of Physics. [doi:10.1063/1.3585871]“
“Objective To compare the efficacy of metformin and clomiphene citrate (CC) therapies for ovulation induction in anovulatory infertile women with polycystic ovary syndrome (PCOS).

Methods A total of 69 consecutive infertile, anovulatory women with PCOS were enrolled in this prospective, non-randomized trial. The women were prescribed either 1,700 mg/day metformin or CC with a starting dose of 50 mg/day up to 150 mg/day for a period of six consecutive cycles.

Results Metformin and CC groups were followed for a total of 136 and 94 cycles, respectively. Metformin group had lower rates of ovulation when compared with CC group (32.3 vs. 60.6%, respectively; p = 0.004). There was no statistical difference in pregnancy rates per cycle between the treatment groups (8 vs. 11.7%, respectively; p = 0.33) leading to similar cumulative pregnancy rates (36.6 vs. 35.4%, respectively; p = 0.45). No difference was observed among the abortion rates (10 vs. 10%, respectively; p > 0.05) between the groups.

Physicians may be able to prevent DIP by prescribing neuroleptic agents appropriately and with caution. The risk of DIP is presumably lower with the use of “”atypical”" antipsychotic agents but it is not eliminated, especially

in those most vulnerable to parkinsonism (eg, the elderly or cognitively impaired). The best treatment is discontinuation of the provoking medication. Prospective studies are needed to further E7080 in vitro define the mechanism of DIP, identify individual susceptibility, determine the impact of atypical antipsychotic agents, and develop further treatment options for those unable to stop the offending agent.”
“Background: The importance of the stabilizing effect of the distal interosseous membrane on the distal radioulnar joint, especially in patients with a distal oblique bundle, has been described. The purpose of this study was to evaluate the stability of the distal radioulnar joint after an ulnar Shortening osteotomy and to quantify longitudinal resistance NCT-501 to ulnar shortening when the osteotomy was proximal or distal to the ulnar attachment of the distal interosseous membrane. These relationships were

characterized for forearms with or without a distal oblique bundle.

Methods: Ten fresh-frozen cadavers were used. A transverse osteotomy and ulnar shortening was performed proximal (proximal shortening) and distal (distal shortening) to the ulnar attachment of the distal interosseous membrane. Distal radioulnar joint laxity was evaluated as the volar and dorsal displacements of the radius relative to the fixed ulna with 20 N of applied force. Testing was performed under controlled 1-mm increments of ulnar shortening up to 4 mm, with the forearm in neutral alignment, 60 degrees of pronation, and 60

degrees of supination. Resistance to ulnar shortening was quantified as the slope of the load-displacement curve obtained by displacing the distal ulnar segment proximally.

Results: In proximal shortening, significantly greater stability of the distal radioulnar joint was obtained with even 1 mm of shortening compared with the control, whereas distal shortening demonstrated significant improvement in stability of the distal radioulnar Prexasertib in vivo joint only after shortening of >= 4 mm in all rotational positions. Significantly greater stability of the distal radioulnar joint was achieved with proximal shortening than with distal shortening and in specimens with a distal oblique bundle than in those without a distal oblique bundle. The longitudinal resistance to ulnar shortening was significantly greater in proximal shortening than in distal shortening. The stiffness in proximal shortening was not affected by the presence of a distal oblique bundle in the distal interosseous membrane.

“”Hot”" excited O atoms (with kinetic energy similar to 2 eV) have been detected.(c) 2010 American Institute of Physics. [doi: 10.1063/1.3525245]“
“Clevudine shows high rates of virologic and biochemical responses in patients with chronic hepatitis B. However, the efficacy and safety of clevudine in patients with cirrhosis are unknown. The aims of this study were to evaluate the safety and to assess the

virologic and the biochemical responses to clevudine in patients with cirrhosis with chronic hepatitis B virus (HBV) infection. We reviewed data from treatment-naive patients with chronic hepatitis B with and without cirrhosis who started clevudine between April 2007 learn more and March 2008 (n = 52, hepatitis B without cirrhosis n = 21 and chronic hepatitis B with cirrhosis n = 31) at Korea University Ansan/Guro Hospital. All of the patients were treated for more than 48 weeks. The mean age was older in the patients with cirrhosis. Baseline HBV DNA levels were 6.9 and 7.78 log copies/mL

(P = 0.042), and alanine aminotransferase (ALT) levels were 104.9 and 147.4 IU/L (P = 0.204), for those with and without cirrhosis, respectively. Virologic response (HBV DNA < 1000 copies/mL) (87.1%vs 71.4%, P = 0.24) and biochemical response (83.9%vs 80.9%, P = 0.99) at week 48 were not significantly different between selleck chemicals llc the two groups. Early virologic response at week 12 was even higher in the patients with cirrhosis (61.3%vs 28.6%, P = 0.026). Neither ALT flare nor newly onset

hepatic decompensation was found in the patients with cirrhosis, whereas ALT flare was transiently observed in 14.3% of I-BET-762 order the chronic hepatitis group. In conclusion, although clevudine may produce a transient elevation of ALT during the early treatment period, such findings were not observed in patients with cirrhosis and the virologic and biochemical responses of the groups were comparable.”
“Cancer is a complex and highly dynamic process. Genetically engineered mouse models (GEMs) that develop cancer are essential systems for dissecting the processes that lead to human cancer. These animal models provide a means to determine the causes of malignancy and to develop new treatments, thus representing a resource of immense potential for medical oncology. The sophistication of modeling cancer in mice has increased to the extent that now we can induce, study and manipulate the cancer disease process in a manner that is impossible to perform in human patients. However, all GEMs described so far have diverse shortcomings in mimicking the hierarchical structure of human cancer tissues. In recent years, a more detailed picture of the cellular and molecular mechanisms determining the formation of cancer has emerged. This Commentary addresses new experimental approaches toward a better understanding of carcinogenesis and discusses the impact of new animal models.

3%, respectively. Both were found to be highly sensitive phenotypic tests for the detection of MRSA. However, the oxacillin disc diffusion test is much more cost-effective. The MSA-FOX, whose sensitivity was 95.8%, was found to be a highly sensitive, cost-effective screening medium CB-5083 for the detection of MRSA.”
“Persistent pain after

TVT-O procedure is a rare complication. Nerve injuries have been suspected as a cause of persistent pain. We present one case of atypical postoperative pain-pudendal neuralgia following TVT-O procedure-which persisted 3 years after the primary procedure. The patient required surgical removal of the tape, which brought only partial relief. Complete relief from pain was afterwards achieved with repeated local applications of anesthetics with corticosteroids. The recurrent stress urinary incontinence was treated with retropubic TVT. Pudendal nerve irritation was also described after retropubic sling procedure, and the cadaveric dissection indicated the theoretic possibility of nerve injury during retropubic sling procedure. To explain the mechanism of nerve injury, we performed cadaveric dissections on a formalin-embalmed female body. We were able to demonstrate the contact of the needle with the pudendal

nerve after aberrant passage of the inserter.”
“We describe the soluble production of a mouse anti-bovine ribonuclease Selleck Birinapant A single-chain variable fragment (scFv) fused with the Fc region of human IgG1 in Escherichia coil. Two production systems, secretory production using a pelB signal peptide and cytoplasmic production in a trxB/gor double mutant strain with an oxidizing cytoplasm, were investigated for efficient production of soluble and functional scFv-Fc fusion protein. Antigen-binding activity was observed in both systems but almost all of the scFv-Fc that was expressed formed insoluble aggregates. Hence, the co-expression of molecular chaperones was examined. Co-expression of GroEL/GroES showed AZD1390 in vivo a 4.6-fold increase in antigen-binding activity in the

cytoplasmic production system but not in the secretory system. By contrast, the other two chaperones, DnaK/DnaJ/GrpE and trigger factor, had no effect in either production system. The protein solubility was also improved markedly by the co-expression of GroEL/GroES and approximately 70% of the 3A21 scFv-Fc protein was soluble. A practical productivity of more than 10 mg/L was achieved with a simple batch shake-flask culture. These results indicate that the E. coil cytoplasmic production system with oxidizing cytoplasm and molecular chaperones might be one of the choices for the soluble production of scFv-Fcs and other Fc fusion proteins. (c) 2010 Elsevier B.V. All rights reserved.”
“In the present study, we investigated the function of the heterotrimeric G protein beta-subunit (G beta) gene (RGB1) in rice.

Occurrence of NTDs was evaluated at embryonic day 11.5 and compared between wild type (WT) and PKC delta homozygous (pkc delta(-/-)) embryos. Changes in oxidative and endoplasmic reticulum (ER) stress-associated factors and stress-response c-Jun N-terminal kinases (JNKs) were assessed PD173074 using Western blot assay. Results: Compared to DM/WT, the DM/PKC delta(-/-) embryos had significantly lower NTD rate and lower levels of oxidative and ER stress factors and JNK activation. These

values were similar to those in the non-diabetic control group. Conclusion: PKC delta plays a critical role in diabetes-induced NTDs, potentially through increasing oxidative and ER stress and JNK-associated stress-response pathways.”
“An in vitro perfusion model of human

placenta was used to study the transplacental passage of iron applied in the form of the drug compound ferric carboxymaltose (FCM) which had been radio-labelled with (59)Fe. In four placental perfusion experiments, two simulated circuits for the maternal and fetal sides of the placenta were set up with two experimental phases each lasting 3 h. FCM was added click here to the maternal circuit at the beginning of each phase to a final iron concentration of 11 mM, which is at least 10 times higher than the maximal predicted level in blood after an administration of 200 mg iron as FCM. The effects of adding transferrin at a physiological concentration of 1.67 mg/ml were also tested.

The concentration profiles of 59Fe showed a 10% decrease within the first 30 min of perfusion on the maternal side. Thereafter the radioactivity levels remained unchanged. The addition of transferrin had no effect on the tissue uptake of (59)Fe-FCM. No transferred

iron radioactivity could be detected in the fetal circuit. Despite a loss of approximately 10% of the radio-labelled iron observed on the maternal side, only 0.5-2% of the radioactivity was detected in the placental tissue after perfusion.

No free iron could be detected at the end of perfusion on the maternal side using ultrafiltration or acid precipitation methods. In addition, the production of transferrin receptor remained unchanged, Flavopiridol with similar concentrations in placental tissue before and after perfusion.

No effects of FCM on placental viability were observed in terms of energy metabolism (glucose consumption and lactate production), hormone release or placental permeability (assessed by the transfer rates of creatinine and antipyrine). However, two additional observations were made: firstly, a significant reduction in the rate of cell death compared to control conditions was observed in the presence of FCM; secondly, the integrity of the fetal capillary system was improved on the fetal side of the perfusion system. It is concluded that the iron compound FCM does not cross the placenta and may increase the integrity of placental tissue (at least under in vitro conditions), but this latter observation needs further investigation.

Finally, clinical relevance of this circuitry is illustrated through a discussion of frontotemporal dementia, traumatic brain injury, and sociopathy.

(The Journal of Neuropsychiatry and Clinical Neurosciences 2012; 24:266-277)”
“Venous thromboembolism, manifested as either deep venous thrombosis or pulmonary embolism (PE), is a major cause of morbidity and mortality in patients admitted to the intensive care unit. Clinically, PE may present as massive thromboembolism associated with cardiogenic shock or may be asymptomatic, as may occur with anatomically small emboli without hemodynamic or respiratory compromise. The management of venous thromboembolism in the critically ill this website patient can be exceedingly complex. The main treatment objectives are the prevention of recurrent PE and, in case of hemodynamic compromise, definitive therapy for deep venous thrombosis or PE involving removal of thrombus. Prevention of recurrent PE is accomplished PF-03084014 molecular weight with anticoagulation and/or placement of an inferior vena cava filter. Definitive therapy involves thrombolysis and surgical or catheter embolectomy. Fluid and vasoactive therapy with norepinephrine may be indicated for refractory hypotension

in patients with massive PE. (C) 2009 Elsevier Inc. All rights reserved.”
“A heterojunction Mott field effect transistor (FET) is proposed that consists of an epitaxial channel material that exhibits an electron correlation induced Mott

find more metal-to-insulator transition. The Mott material is remotely (modulation) doped with a degenerately doped conventional band insulator. An applied voltage modulates the electron transfer from the doped band insulator to the Mott material and produces transistor action by inducing an insulator-to-metal transition. Materials parameters from rare-earth nickelates and SrTiO(3) are used to assess the potential of the “”modulation-doped Mott FET”" (ModMottFET or MMFET) as a next-generation switch. It is shown that the MMFET is characterized by unique “”charge gain”" characteristics as well as competitive transconductance, small signal gain, and current drive. (C) 2011 American Institute of Physics. [doi:10.1063/1.3651612]“
“For more than half a century, electron microscopy has been a main tool for investigating the complex ultrastructure and organization of chloroplast thylakoid membranes, but, even today, the three-dimensional relationship between stroma and grana thylakoids, and the arrangement of the membrane protein complexes within them are not fully understood. Electron cryo-tomography (cryo-ET) is a powerful new technique for visualizing cellular structures, especially membranes, in three dimensions. By this technique, large membrane protein complexes, such as the photosystem II supercomplex or the chloroplast ATP synthase, can be visualized directly in the thylakoid membrane at molecular (4-5nm) resolution.

[doi: 10.1063/1.3556781]“
“Informed by the findings from prospective observational studies and randomized outcome trials, guidelines for the management of hypertension acknowledge that the benefit of treatment can be attributed largely to blood pressure (BP) reduction. Therefore, quantification of differential BP lowering of different agents within classes of anti-hypertensives is of practical importance. The objective of this analysis was to compare the efficacy of candesartan and losartan with respect to reduction in systolic and diastolic BP (SBP and DBP). A systematic literature search of databases from 1980 to 1 October 2008 identified 13 studies in which Dactolisib molecular weight candesartan

and losartan were compared in randomized trials in hypertensive patients. Data from 4066 patients were included in the analysis using a random effect model. Mean changes in SBP and DBP were compared for each drug alone and after stratification for dose and for combination with hydrochlorothiazide (HCTZ). On the basis of all the data, the weighted

mean difference favoured candesartan-3.22 mm Hg (95% confidence interval (CI) 2.16, 4.29) for SBP and 2.21 mm Hg (95% CI 1.34, 3.07) for DBP. These findings were consistent when analyses according to dose and combination with HCTZ were carried out. Thus, it can be concluded that at currently recommended doses, candesartan is more effective than losartan in lowering BP.”
“Background and aim: The results from studies published on the association of fatty acid-binding protein 2 (FABP2) PF-03084014 price Ala54Thr polymorphism with body mass index (BMI) are conflicting. In this meta-analysis, we investigated the association of the FABP2 Ala54Thr polymorphism with BMI.

Methods and results: We searched for articles published prior to June 2009 using PubMed, HugeNavigator and China National Knowledge Internet. The

languages were limited to English and Chinese. Data on BMI were collected. A pooled weighted mean difference (WMD), together with 95% confidence interval (CI), was used for this meta-analysis.

A total of 27 studies with 10 974 subjects were included in this meta-analysis. The pooled effect for dominant, recessive and co-dominant model comparisons did not suggest the significant association between selleck inhibitor the FABP2 Ala54Thr polymorphism and BMI in overall populations: WMD(fixed) (effects) = -0.00, 95% CI: (-0.16 to 0.15), p = 0.99, WMD(random effects) = -0.00, 95% CI: (-0.16 to 0.15), p = 0.99, p(Q) = 0.77, I(2) = 0%, WMD(fixed effects) = -0.12, 95% CI: (-0.39 to 0.14), p = 0.35, WMD(random) (effects) = -0.12, 95% CI: (-0.39 to 0.14), p = 0.35, p(Q) = 0.47, I(2) = 0% and WMD(fixed) (effects) = 0.07, 95% CI: (-0.11 to 0.25), p = 0.45, WMD(random) (effects) = 0.07, 95% CI: (-0.11 to 0.25), p = 0.45, p(Q) = 0.90, I(2) = 0%, respectively.

Dietary SID Leu and Val were set to 1.05 and 0.66%. For the 42-d period, ADG, ADFI, and G: F increased linearly (P < 0.01) and quadratically (P < 0.01) with increasing SID Ile: Lys. Estimated optimal SID Ile: Lys ratios were 54, 54, and 49 for ADG, ADFI, and G: F, respectively. These experiments suggest that the optimal SID Ile: Lys ratio depends on diet composition. In Exp. 1, AA imbalances because of increased Leu contents may have led to increased Ile nutritional needs. For ADG and ADFI, an optimum SID Ile: Lys ratio of 54% was estimated for 8- to 25-kg pigs in diets without Leu

excess.”
“An attempt was made to toughen diglycidyl ether of bisphenol A (DGEBA) type epoxy resin with liquid natural rubber possessing hydroxyl functionality (HTLNR). Epon 250 epoxy monomer is cured using nadic methyl anhydride as hardener in presence of N, N dimethyl benzyl amine as accelerator. selleck inhibitor HTLNR of different concentrations up to 20 wt % is used DMXAA mouse as modifier for epoxy resin. The addition HTLNR to an anhydride hardener/epoxy monomer mixture has given rise to the formation of phase-separated structure, consisting of small spherical liquid natural rubber particles bonded to the surrounding epoxy matrix. The particle size increased with increase in rubber content. The viscoelastic properties of the blends were analyzed using dynamic mechanical thermal analysis. The Tg corresponding to epoxy rich

phase was evident from the dynamic mechanical spectrum, while the Tg of the rubber phase was overlapped by the beta relaxation of epoxy phase. Glass transition of the epoxy phase decreased linearly as a function of the amount of rubber. The mechanical properties such as impact MLN2238 clinical trial and fracture toughness were also carefully examined. The impact and fracture toughness increase with HTLNR content. A threefold increase in impact strength was observed with 15 wt % HTLNR/epoxy blend. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Leakiness (phi), the proportion of

carbon fixed by phosphoenolpyruvate carboxylation that leaks out of the bundle-sheath cells, determines C-4 photosynthetic efficiency. Large increases in phi have been described at low irradiance. The underlying mechanisms for this increase remain uncertain, but changes in photorespiration or the energy partitioning between the C-4 and C-3 cycles have been suggested. Additionally, values of phi at low light could be magnified from assumptions made when comparing measured photosynthetic discrimination against C-13 (Delta) with the theoretical formulation for Delta. For example, several simplifications are often made when modelling Delta to predict phi including: (i) negligible fractionation during photorespiration and dark respiration; (ii) infinite mesophyll conductance; and (iii) CO2 inside bundle-sheath cells (C-s) is much larger than values in mesophyll cells (C-m).

The mean age (and standard deviation) at the final fusion

was 12.4 +/- 1.9 years. In forty-four (55%) of eighty patients for whom the information was available, the number of vertebral levels fused was the same as the number of vertebral levels spanned by the growing rods. The percent correction of the curve after final fusion was none or minimal (<= 20%) in eleven (18%) of the sixty-two patients for whom sufficient-quality radiographs were available, moderate (21% to 50%) DMH1 manufacturer in thirty (48%), and substantial (>= 51%) in nine (15%); the curve had worsened in twelve patients (19%). The mean duration of growing-rod treatment was 5.0 +/- 2.6 years. Of fifty-eight operative reports made at final fusion that contained comments on spinal flexibility, eleven (19%) described the spine as being mobile, RAD001 in vitro eleven (19%) described decreased flexibility, and thirty-six (62%) described the spine as being completely stiff. At final fusion, twenty-two patients (24%) had osteotomies and seven patients (8%) had a thoracoplasty.

Conclusions: Most patients underwent growing-rod removal and final instrumented fusion. The final fusion often included the same levels spanned by the growing rods and usually achieved <50% additional correction of the deformity remaining at the end of the growing-rod management.”
“The

temperature-dependent electronic structure of ferromagnetic double perovskite La2MnNiO6

has been investigated by employing soft x-ray magnetic circular dichroism (XMCD) and soft x-ray absorption spectroscopy (XAS). The measured 2p XAS spectra for Mn and Ni ions at low temperature show that most of Mn ions are formally tetravalent (3d(3)) and that Ni ions are divalent (3d(8)). The measured Ni 2p core-level x-ray photoemission spectroscopy spectrum also supports the divalent states of Ni ions. With increasing temperature, the measured XMCD intensity decreases, in agreement with its high Curie temperature. The line shapes of both XMCD and XAS spectra do not change with temperature, suggesting that the valence states of La2MnNiO6 do not change with temperature. (C) 2010 Silmitasertib price American Institute of Physics. [doi:10.1063/1.3340448]“
“Objective: To assess the impact of admission to different hospital types on early and 1-year outcomes in patients with acute coronary syndrome (ACS).

Methods. Between 1997 and 2009, 31010 ACS patients from 76 Swiss hospitals were enrolled in the AMIS Plus registry. Large tertiary institutions with continuous (24 hour/7 clay) cardiac catheterisation facilities were classified as type A hospitals, and all others as type B. For 1-year outcomes, a subgroup of patients admitted after 2005 were studied.

Results: Eleven type A hospitals admitted 15987 (52%) patients and 65 type B hospitals 15023 (48%) patients.