“Induction

of oxidative stress and inhibition of D


“Induction

of oxidative stress and inhibition of DNA repair are possible modes of arsenic-induced carcinogenesis. In West Bengal, India, several districts contain high levels of arsenic, which are far above the WHO-recommended standard. Prevention of arsenic-induced oxidative stress and induction of repair enzymes by curcumin, an active ingredient of turmeric, may be an effective strategy to combat the adverse effects of arsenic. This study aimed at observing the role of curcumin in reducing 8-hydroxy-2′-deoxyguanosine formation and enhancing DNA repair capacity in the arsenic-exposed population of West Bengal. Chronically find more arsenic-exposed volunteers (n=66), who were asymptomatic, were selected for this study. Our results indicated that curcumin suppressed the 8-hydroxy-2′-deoxyguanosine level and OGG1 expression, which were increased by arsenic. Curcumin also induced DNA repair enzymes involved in the both base excision repair and nonhomologous end-joining pathways. In this study, both the protein expression and genetic profile were observed for poly-ADP-ribose polymerase 1, DNA beta polymerase, X ray repair cross complement 1, DNA ligase III, DNA protein kinase catalytic sub-unit, X ray repair cross complement 4, DNA ligase IV, and topoisomerase II beta. The results indicated that arsenic-inhibited DNA repair was induced by curcumin, both at

protein and genetic levels. Thus, curcumin intervention may Alvocidib concentration be a useful modality for the prevention of arsenic-induced carcinogenesis. European Journal of Cancer Prevention 20: 123-131 buy Fer-1 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“The jacitara palm (Desmoncus polyacanthos Mart.) is widely used by the artisans of the Amazon Basin region of Negro River, Brazil, and is known to provide excellent fiber characteristics and appearance. However, there is a lack of technical/scientific information about this important vegetable fiber. The objective of this study was to evaluate the main properties of jacitara fibers for their future technological

application as reinforcement in composites. Anatomical, ultrastructural, chemical, physical and mechanical tests were performed. The coefficient of rigidity, fraction wall, Runkel index and aspect ratio results showed the potential of the jacitara fibers as reinforcement in composites. The range of the microfibrillar angle of the fibers was 12.8-16.5. The average contents of cellulose, hemicellulose, lignin, extractives and mineral components were 66.9%, 18.4%, 14.7%, 11.6% and 1.8%, respectively. Fibers extracted from the bottom or from the medium part of the jacitara stem showed higher modulus of elasticity (1.9 GPa and 1.7 GPa, respectively) and tensile strength (74.4 MPa and 70.6 MPa, respectively) than that extracted from the upper part. The properties of the jacitara fibers are in the same range of other lignocellulosic materials.

We suggest that autophagy constitutes a ‘pro-survival’ mechanism

We suggest that autophagy constitutes a ‘pro-survival’ mechanism that controls the containment

of host tissue-destructive microbial infections. In contrast, atg plants do not show spreading necrosis, but exhibit marked resistance against the virulent biotrophic phytopathogen, Pseudomonas syringae pv. tomato. Inducible defenses associated with basal plant immunity, such as callose production or mitogen-activated protein kinase activation, Ulixertinib ic50 were unaltered in atg genotypes. However, phytohormone analysis revealed that salicylic acid (SA) levels in non-infected and bacteria-infected atg plants were slightly higher than those in Col-0 plants, and were accompanied by elevated SA-dependent gene expression and camalexin production. This suggests that previously undetected moderate infection-induced rises in SA result in measurably enhanced bacterial resistance, and that autophagy negatively controls SA-dependent

defenses and basal immunity to bacterial infection. We infer that the way in which autophagy contributes selleck chemical to plant immunity to different pathogens is mechanistically diverse, and thus resembles the complex role of this process in animal innate immunity.”
“We investigated the potential neuroprotective effects of leptin (LEP) against cellular damage, long-term recurrent spontaneous seizures, and behavioral changes associated with kainate (KA)-induced status epilepticus (SE). Adult Sprague-Dawley rats were sacrificed 24 hours after KA injections, and hippocampi were subjected to histological analysis. In the acute condition, one group received 12 mg/kg KA intraperitoneally (KAac group), and another group received 12 mg/kg KA intraperitoneally, followed by two intraperitoneal LEP injections of 4 mg/kg each, 1 and 13 hours after KA (KALEPac group). For long-term outcomes, one group received KA (KA group), and the other group received three intraperitoneal LEP injections (4 mg/kg at 1 hour,

and 2 mg/kg at 13 and 24 hours) after KA (KALEP group). Controls were sham manipulated. Behavioral tests started 6 weeks after SE. All NSC23766 in vivo rats that received KA underwent behavioral seizures of comparable severity. Compared with the KAac group, the KALEPac group had significantly larger pyramidal cell surface areas and fewer black-stained degenerating neurons with silver stain. The KALEP and KA groups were comparable with respect to recurrent spontaneous seizures, aggression, hyperactivity, and impaired memory. We show that leptin reduces cellular injury associated with KA-induced SE, but does not prevent long-term recurrent spontaneous seizures and behavioral deficits. (C) 2010 Elsevier Inc. All rights reserved.”
“As part of the Universidade Estadual do Norte Fluminense recurrent selection program of popcorn, we evaluated full-sib families of the sixth cycle of recurrent selection and estimated genetic progress for grain yield and expansion capacity.

Twenty-two fungal isolates

Twenty-two fungal isolates Nepicastat were obtained, some of which were identified as Alternaria alternata, Aspergillus flavus, Bipolaris hawaiiensis, Fusarium merismoides, Lasiodiplodia theobromae, Penicillium citrinum, Penicillium crustosum, Penicillium janthinellum, Penicillium purpurogenum, Pestalotiopsis

palustris, Tetracoccosporium paxianum andTrichoderma koningii. These fungi were grown in liquid media to obtain crude extracts that were evaluated for their antibiotic activity against pathogenic bacteria, yeast and Cladosporium cladosporioides and A. flavus. The most active extract was obtained from L. theobromae (minimum inhibitory concentration=64g/mL against Listeria monocitogenes). Some extracts showed to be more active than the positive control in the inhibition of Staphylococcus aureus and L. monocitogenes. Therefore, propolis is a promising source of fungi, which produces active agents against relevant food poisoning bacteria and crop-associated fungi.”
“Two-port network analysis is used to probe the dynamics of the perpendicular recording head. Two identical https://www.selleckchem.com/products/3-methyladenine.html heads are aligned to each other with poletip to poletip on their air-bearing-surface sides, while the spacing is about the typical flying height. With two-port network analysis, forward transmission coefficient measurement

shows the nonuniformity of the frequency response across the footprint Lazertinib ic50 of the poletip. It is suggested that the spatial distribution of the fast-field

pulse can be optimized by constructing the fast write pulse with proper frequency components. In addition, the head-to-media recording performance is characterized by contact scanning recording tester. A single 0.15 ns/50 mA current pulse is good enough to complete the recording. c 2009 American Institute of Physics. [DOI: 10.1063/1.3074512]“
“There is a wealth of research exploring the psychological consequences of infertility and assisted reproduction technology, a substantial body of sociological and anthropological work on ‘reproductive disruptions’ of many kinds and a small but growing literature on patient perspectives of the quality of care in assisted reproduction. In all these fields, research studies are far more likely to be focused on the understandings and experiences of women than those of men. This paper discusses reasons for the relative exclusion of men in what has been called the ‘psycho-social’ literature on infertility, comments on research on men from psychological and social perspectives and recent work on the quality of patient care, and makes suggestions for a reframing of the research agenda on men and assisted reproduction.

parapertussis infection We conclude that B pertussis, through t

parapertussis infection. We conclude that B. pertussis, through the action of PT, can enhance a B. parapertussis infection, possibly by an inhibitory effect on innate immunity.”
“Background: In 2006, the Philadelphia Department of Public Health conducted an investigation of a varicella outbreak

at an elementary school in which second-dose vaccination for outbreak control (VOC) was implemented. We evaluated the effectiveness of this intervention.

Methods: Self-administered questionnaires collected varicella disease Rigosertib price and vaccination information. Students eligible for second-dose VOC were 1-dose vaccine recipients without prior varicella disease. A breakthrough varicella case was defined as a maculopapulovesicular rash in a student with onset >42 days after 1-dose vaccination without other apparent cause. Vaccine effectiveness was evaluated using survival analysis techniques and analyzed by vaccine status (first dose versus second dose). Multivariable Cox proportional hazard models were used to identify statistical interactions and adjust for confounders.

Results: The questionnaire response rate was 92% (342/370). Of the 286 eligible students, 187 (65%) received a second-dose VOC. The crude attack rate was 9/187

(5%) among second-dose check details VOC recipients; 43/99 (43%) among 1-dose recipients, and 5/6 (83%) among unvaccinated students. Second-dose VOC recipients had milder rashes, compared with 1-dose or unvaccinated students. The adjusted incremental second-dose vaccine effectiveness was 76% (95% confidence interval: 44%-90%) for students with classroom exposure. Incremental effectiveness was similar (79%) when we extended the immune response time from 4 days to 7 days after second-dose VOC.

Conclusions: Second-dose VOC resulted in a substantial reduction in varicella incidence for students with classroom exposure. Until high rates of routine second-dose vaccine coverage are achieved, clinicians should consider second-dose

VOC an appropriate intervention to reduce disease transmission in institution-based outbreaks.”
“The dielectric and magnetic properties of manganese oxide-coated Fe3O4 nanoparticles (NPs) were measured by the transmission/reflection method in 2-18 GHz. MnOx-coated Fe3O4 NPs were prepared by sol-gel method followed Rigosertib ic50 by heat-treating at 300, 400, and 500 degrees C, respectively. The heat-treated powders were then used as magnetic fillers and added to an epoxy resin to prepare MnOx-coated Fe3O4 composites for the complex permittivity (epsilon’-j epsilon ”) and permeability (mu’-j mu ”) measurements. After the sol-gel process, the coating of manganese oxide ( mixture of major Mn2O3 and minor Mn3O4) reduced the value of epsilon’. The lower the heat-treating temperature, the larger the decrease in epsilon’. The relative decrease in epsilon’, compared with uncoated Fe3O4 nanoparticles, is 28.7, 23.

” Prioritization of adherence is accomplished through resources

” Prioritization of adherence is accomplished through resources and help made available by treatment partners, other family members and friends, and health care providers. Helpers expect adherence and make their expectations known, creating a responsibility on the part of patients to adhere. Patients adhere to promote good will on the part of helpers, thereby ensuring help will be available

when future needs arise.

Conclusion

Adherence success in sub-Saharan Africa can be explained as a means of fulfilling social responsibilities and thus preserving social capital in essential relationships.”
“The present case illustrates pulmonary AMN-107 molecular weight vein isolation guided by real-time three-dimensional transesophageal echocardiography.

This imaging modality allowed to navigate in a point-by-point fashion around pulmonary veins to assess both catheter location in relation to pulmonary vein ostia and stability of catheter tip. Also, it offered high-resolution visualization of a thickened, prominent tissue that surrounded the left upper pulmonary vein (the ligament of Marshall). The ability to visualize this anatomical structure along with intracardiac recording of electrical signals allowed to safely modulate in loco radiofrequency energy delivery, thus achieving electrical isolation of the pulmonary vein. (PACE 2011; 14)”
“Garcinia indica Choisy Syn Brindonia indica, commonly known as kokum and belonging CBL0137 concentration to Guttiferae family, is a plant native to certain regions of India. The trees yield fruits annually in the summer season during the months of March to May. The fruits are green when raw and red to dark purple when fully Vorinostat order ripe. They are used to prepare juice, pickles and as acidulant in curries. In the traditional Indian system of medicine the Ayurveda and in various folk systems

of medicine, the fruit rinds and leaves are used to treat various inflammatory ailments, rheumatic pain and bowel complaints. The kokum butter prepared from the seed is of both commercial and medicinal use. Chemical studies have shown that the rind contains protein, tannin, pectin, sugars, fat, organic acids like (-)-hydroxycitric acid, hydroxycitric acid lactone and citric acid; the anthocyanins, cyanidin-3-glucoside and cyanidin-3-sambubioside; and the polyisoprenylated phenolics garcinol and isogarcinol. Preclinical studies have shown that kokum or and some of its phytochemicals possess antibacterial, antifungal, anti-ulcerogenic, cardioprotective, anticancer, chemopreventive, free radical scavenging, antioxidant and anti-obesity effects. The present paper reviews the nutritional value, the phytochemical compounds, traditional uses and validated pharmacological properties of kokum. (C) 2011 Elsevier Ltd. All rights reserved.

In the circulation, iron is transported to target organs bound to

In the circulation, iron is transported to target organs bound to the serum iron binding protein transferrin. Individual cells modulate their uptake Nepicastat clinical trial of transferrin-bound iron depending on their iron requirements, using both transferrin receptor 1-dependent and independent pathways. Once inside the cell, iron can be chaperoned to sites of need or, if in excess, stored within ferritin. Iron is released from cells by the iron export protein ferroportin1, which requires the ferroxidase activity of ceruloplasmin or hephestin to load iron

safely onto transferrin. The regulation of iron export is controlled predominantly at the systemic level by the master regulator of iron homeostasis hepcidin. Hepcidin, in turn, responds to changes in body iron demand, making use of a range of regulatory mechanisms that center on the bone morphogenetic buy Combretastatin A4 protein signaling pathway. This review provides an overview of recent advances in the field of iron metabolism and outlines

the key components of the iron transport and regulation systems. (c) 2013 BioFactors, 40(2):206-214, 2014″
“Flavonoids have biofunctional effects as antioxidant and antimicrobial agents. The objective of this study was to evaluate the bactericidal activity and antilipopolysaccharide (LPS) effects of flavonoids on Escherichia coli O157:H7. The effects of flavonoids on the growth of E coli O157:H7 were bacteriostatic rather than bactericidal at concentrations below 200 mu M, and there was no significant difference among the flavonoids tested (p<0.05). LPS production in E coli O157:H7 treated with 200 mu M quercetin and naringenin decreased by 34.06 +/- 1.03 and 19.90 +/- 1.51%, respectively, relative

to the https://www.selleckchem.com/products/lazertinib-yh25448-gns-1480.html control (no flavonoid). Luteolin, genkwanin, hesperetin, and apigenin caused decreases in LPS production of 69.85 +/- 1.03, 61.18 +/- 1.15, 60.74 +/- 1.10, and 58.93 +/- 0.98%, respectively, relative to the control. Based on these results, luteolin had the greater inhibitory effect on LPS production by E. coli O157:H7 than other flavonoids tested in this study.”
“Macrophages are among the first cellular actors facing the invasion of microorganisms. These cells are able to internalize pathogens and destroy them by means of toxic mediators, many of which are produced enzymatically and have strong oxidizing capacity. Indeed, macrophages count on the NADPH oxidase complex activity, which is triggered during pathogen invasion and leads to the production of superoxide radical inside the phagosome. At the same time, the induction of nitric oxide synthase results in the production of nitric oxide in the cytosol which is able to readily diffuse to the phagocytic vacuole. Superoxide radical and nitric oxide react at diffusion controlled rates with each other inside the phagosome to yield peroxynitrite, a powerful oxidant capable to kill micro-organisms.

The mammalian cells became persistently infected with R montanen

The mammalian cells became persistently infected with R. montanensis and produced low levels of rickettsiae. On the other hand, superinfection of the R. montanensis-infected GSK923295 cell line cells with R. japonica resulted in increased yields of R. montanensis accompanied by R. japonica growth. Both rickettsiae also grew well in the R. japonica-infected cells

subjected to superinfection with R. montanensis. Western blotting with an antibody to the autophagy-related protein LC3B found that autophagy was induced in the cells infected with R. montanensis alone. On the contrary, autophagy was restricted in the cells that were co-infected with R. japonica. Electron microscopy of the cells infected with R. montanensis

alone demonstrated rickettsia particles being digested in intracytoplasmic vacuoles. Conversely, many freely growing rickettsiae were detected in the co-infected cells.”
“Purpose: To evaluate imaging utilization trends in patients with acute pancreatitis (AP) and to assess independent predictors of radiology usage in relation to patient outcomes.

Materials and Methods: Institutional review board approval was obtained for this HIPAA-compliant study; written informed consent was waived. AP-related radiologic studies in 252 patients admitted for AP between June 2005 and December 2007 were collected during and for a 1-year period after hospitalization. Clinical data were collected from patients’ medical records, while imaging data were obtained from the radiology information system. Selleckchem JQ1 Linear regression models were used to investigate predictors and time trends of imaging utilization, after adjustment for confounders. Patient outcomes, measured by using mortality, intensive care unit admission, need for surgical intervention, organ failure, Elafibranor order and persistent systemic inflammatory

response syndrome, were evaluated by using logistic regression.

Results: Mean utilization was 9.9 radiologic studies per patient (95% confidence interval: 7.5, 12.3), with relative value unit (RVU) of 7.8 (95% confidence interval: 6.3, 9.4). Utilization was highest on day 0, declining rapidly by day 4; 53% of imaging occurred during initial hospitalization. Chest radiography (38%) and abdominal computed tomography (CT) (17%) were the most commonly performed studies. Patients with longer hospital stay (P = .001), higher Acute Physiology and Chronic Health Evaluation II score (P = .0012), higher pain levels (P = .003), drug-induced AP (P = .002), and prior episodes of AP (P < .001) underwent significantly more radiologic studies. After adjustment for confounders, a 2.5-fold increase in the use of high-cost (CT and magnetic resonance imaging) examinations and a 1.4-fold increase in RVUs per case-mix-adjusted admissions (P < .05) were observed during the 2.5-year study period.

All rights reserved “
“Background: Dairy foods are nutrient

All rights reserved.”
“Background: Dairy foods are nutrient rich but also a source of saturated fat in the diets of children.

Objective: We assessed effects on dietary intakes and health outcomes of changing dairy foods consumed MK-2206 by children from regular-to reduced-fat varieties.

Design:

This study was a 24-wk cluster randomized controlled trial in 93 families with 4-13-y-olds who were randomly allocated to parental education regarding changing to reduced-fat dairy foods (n = 76 children) or reducing screen time (n = 69 children). Study outcomes, which were measured at weeks 0, 12 (end of the intervention), and 24, included saturated fat, energy, and nutrient intakes; pentadecanoic acid and blood lipid concentrations; body mass index z score; and waist circumference. Multilevel analyses were used with adjustment selleck for child-and family-level covariates.

Results: There were no group differences in overall dairy intakes (-45 g dairy; 95% CI: -141, 51 g dairy; P = 0.356). Saturated fat intakes were 3.3 percentage points lower (P < 0.0001) in the intervention group at week 24 than in the comparison group. Pentadecanoic acid concentrations were lower at week 12 (0.03%; P = 0.012) but not at week 24. LDL-cholesterol concentrations were not different at week 12, but LDL-cholesterol concentration was 0.15 mmol/L lower in the intervention group at week 24 than in the comparison

group (P = 0.037). There were no significant group differences in total energy or adiposity measures. Regular-fat dairy foods decreased from 88% to 14% of dairy intake in the intervention group. Calcium, magnesium, and carbohydrate (percentage of energy) intakes were higher in the intervention group than in the comparison group; retinol intakes were lower in the intervention group than in the comparison group; and overall vitamin A intakes were similar between groups.

Conclusion: Advice to parents to change to reduced-fat products was effective in reducing children’s saturated fat intakes but did not alter energy intakes or measures of adiposity. This trial

learn more was registered in the Australia New Zealand Clinical Trials Registry as ACTRN12609000453280. Am J Clin Nutr 2011;93:1117-27.”
“Artificial membranes are ideal supports for enzyme immobilization and biocatalysis. The binding of a commercial lipase, Lipolase T20 on to nitrocellulose (NC) membrane was achieved by physical adsorption followed by cross-linking with formalin (2%). The NC-immobilized lipase was characterized for its catalytic activity and operational stability, using p-nitrophenyl palmitate (p-NPP) hydrolysis as a model reaction system. Functionally membrane bound lipase was more stable than free lipase (55 degrees C) at higher temperature (65 and 75 degrees C) and at pH 9.0 to 9.5. The hydrolytic properties of NC-bound lipase were studied consecutively as a function of physicochemical parameters. The NC-bound lipase was highly hydrolytic toward relatively longer C-chain length esters.

Strong medical indications as a percentage of all deliveries did

Strong medical indications as a percentage of all deliveries did not change significantly over time (P=.99).

CONCLUSION: Our quality collaborative reduced scheduled deliveries of medically unnecessary and intermediate indications for delivery at 36 0/7 and 38 6/7 weeks. However, scheduled deliveries with strong medical indication find more did not change significantly over time. (Obstet Gynecol 2012; 120: 241-5) DOI: 10.1097/AOG.0b013e318260d9b2″
“Objective

The objective of this study was to evaluate laterality and upper/lower face dominance of expressiveness during prescribed speech using a unique validated image subtraction system capable of sensitive and reliable measurement of facial surface deformation.

Rationale Observations and experiments of central control of facial expressions during speech and social utterances in humans and animals suggest that the right mouth moves more than the left during

nonemotional speech. However, proficient lip readers seem to attend to the whole face to interpret meaning from expressed facial cues, also implicating a horizontal (upper face-lower face) axis.

Study Design Prospective experimental design. Experimental maneuver: recited speech. Outcome measure: image-subtraction strength-duration curve amplitude.

Methods Thirty normal human adults were evaluated during memorized nonemotional recitation of 2 short sentences. Facial movements were assessed using a video-image subtractions system Epigenetics inhibitor capable of simultaneously measuring upper and lower specific areas of each hemiface.

Results The results demonstrate both axes influence facial expressiveness in human communication; however, the horizontal axis (upper versus lower face) would appear dominant, especially during what would appear to be spontaneous breakthrough unplanned expressiveness.

Conclusion S3I-201 purchase These data are congruent with

the concept that the left cerebral hemisphere has control over nonemotionally stimulated speech; however, the multisynaptic brainstem extrapyramidal pathways may override hemiface laterality and preferentially take control of the upper face. Additionally, these data demonstrate the importance of the often-ignored brow in facial expressiveness.

Level of Evidence Experimental study. EBM levels not applicable.”
“The human epididymal protease inhibitor (Eppin) gene is specifically expressed in testis and epididymis and is important in mate reproduction. However, to date, there is no report on variants of this gene, particularly in relation to mate fertility. To investigate the association between Eppin genetic variants and semen quality, variant genotyping and semen analysis was performed in 473 mates with definite idiopathic infertility by polymerase chain reaction-restriction fragment length polymorphism and computer-assisted semen analysis.

This technique has been clinically validated to provide an accura

This technique has been clinically validated to provide an accurate trajectory for pedicle screw placement in the cervical spine.”
“Background: Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs), which have been evolutionarily conserved in microbes. Human melanocytes are not simply pigment-producing cells but also have the phagocytic capacity and can produce pro-inflammatory mediators. However, the mechanisms of recognition of microbes by melanocytes have not yet been fully established.

Objective: We investigated Sapitinib supplier the TLRs 1-10 expression profile in human epidermal melanocytes and assessed their functions after triggering

by their specific ligands.

Methods: TLRs mRNA expression was determined by RT-PCR, and the TLR protein expression was measured by flow cytometry and immunofluorescence assays. After stimulation with various TLR ligands, the production of inflammatory cytokine IL-8 and IL-6 was measured by ELISA and them RNA for chemokine CCL2, CCL3 and CCL5 was analyzed by real-time PCR. Phosphorylation of I kappa B alpha in TLR ligands-triggered melanocytes was determined by Western blot and the nucleus

translocation of NF-kappa Bp65 was analyzed by immunofluorescence.

Results: Human melanocytes constitutively expressed TLRs 1-4, 6, 7 and 9 mRNA. Ample amounts of TLRs 2-4, 7 and 9 were confirmed at protein level. Stimulation of melanocytes with TLRs ligands resulted in the release of cytokines (IL-8 and IL-6) and the mRNA accumulation of chemokines (CCL2, CCL3 and CCL5). Triggering of TLRs in melanocytes Nepicastat molecular weight resulted in the up-regulation of phosphorylated I kappa B alpha and PU-H71 manufacturer in the nucleus translocation of NF-kappa Bp65.

Conclusion: Present study indicates human melanocytes express a panel of functional TLRs. The ligation of TLRs can turn these cells into active players of the skin innate immunity. (C) 2009 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.”
“Study Design. A case report.

Objectives. To report a case of progressive kyphoscoliosis associated with a tethered cord that was corrected by posterior vertebral

column resection after complicated untethering surgery.

Summary of Background Data. There have been few clinical reports on posterior vertebral column resection conducted for severe deformity associated with a tethered cord.

Methods. A patient with progressive kyphoscoliosis associated with a tethered cord first underwent untethering surgery, resulting in neurologic deterioration. Posterior vertebral column resection was performed to correct the kyphoscoliosis while shortening the spinal column to prevent the spinal cord from stretch injury.

Results. Good correction of kyphoscoliosis was obtained without further neurologic deterioration. The Cobb angles of scoliosis was 103 before surgery and 25 after surgery (correction rate; 75.