In the present study, we evaluated the association between the HLA-DRB1 alleles and UC in Han and Uyghur populations from north-west China. We did not find any association between HLA-DRB1 alleles and UC in the Han population, and these results were consistent animal study with previous Chinese studies. L�� et al[19] showed that polymorphism of the HLA-DRB1 gene did not have a strong association with UC in Chinese patients. Lee et al[20] found that HLA-DQa1c, but not HLA-DRB1 alleles, was associated with ANCA-positive UC in southern China. We found differences between Uyghur UC patients and healthy controls, in whom HLA-DRB1*04, HLA-DRB1*13 and HLA-DRB1*14 showed a greater frequency in UC patients than in controls. These results were consistent with previous Japanese studies[21].
In contrast to previous Chinese studies HLA-DRB1*08 showed a lower frequency in UC patients than in controls[22]. Polymorphism of the HLA-DRB1 gene may contribute to the clinical heterogeneity of UC between Han and Uyghur UC patients in China. The results in the present study were different probably due to the statistical methods used and the genetic heterogeneity of the ethnic populations. In future studies, we will continue to explore other HLA genes and amplify our sample size to identify the genes associated with UC in different ethnic groups in China and to provide more evidence for the genetic susceptibility of UC. COMMENTS Background Previous studies have shown that human leukocyte antigens (HLA) alleles are associated with ulcerative colitis (UC).
The clinical characteristics of UC in the Han and Uyghur populations residing in the Xinjiang Uyghur Autonomous Region of China were shown to be different. In this study, the authors examined whether polymorphism of the HLA-DRB1* gene differed between Han and Uyghur patients with UC. Research frontiers Studies have found that disease distribution and phenotypic appearance differ significantly between ethnic groups and even within populations. The genetic and clinical heterogeneity of UC between the two ethnic groups, Chinese Han and Uyghur, were investigated. Innovations and breakthroughs This study found that polymorphism of the HLA-DRB1* gene differed between Han and Uyghur patients with UC. Polymorphism of the HLA-DRB1 gene may contribute to the clinical heterogeneity of UC between Han and Uyghur UC patients in north-west China.
Applications Entinostat The effects of different genotypes in normal controls and patients with UC are still unknown and likely represent a potentially productive area for future research to better understand the pathogenesis and treatment of UC. Terminology UC is a form of inflammatory bowel disease. It is a refractory, chronic, and nonspecific disease which usually occurs in the rectum and the entire colon. HLA, located on chromosome 6, play an important role in the immune response and several immune-mediated diseases.