The United Network for Organ Sharing (UNOS) data set provides an opportunity to examine long-term LTx survivors.

METHODS: We conducted a case-control

study embedded within the prospectively collected UNOS LTx cohort to identify 836 adults from 1987 to 1997 who survived >= 10 years after first LTx. LTx patients within the same era and surviving 1 to 5 years served as controls. Multivariable logistic regression with incorporation of spline terms evaluated the odds of being a 10-year survivor. Two separate models were constructed. Model https://www.selleckchem.com/products/BKM-120.html A incorporated pre-operative, operative, and donor-specific factors. Model B incorporated the factors used in Model A with post-operative Metabolism inhibitor covariates. Additional outcomes evaluated included hospitalizations for infection, rejection, and bronchiolitis obliterans.

RESULTS: Of 4.818 LTx patients from 1987 to 1997, 836 (17.3%) survived >= 10 years with a mean follow-up of 148.8 +/- 21.6 months. Mean follow-up for 1,657 controls was 34.0 +/-

13.9 months. The distribution of 10-year survivors by disease was cystic fibrosis, 170 (20%); chronic obstructive pulmonary disease, 254 (30%); and idiopathic pulmonary fibrosis, 92 (11%). On multivariable logistic regression, significant factors influencing 10-year survival included age <= 35 years (odds ratio [OR] 1.07, 95% confidence interval [CI], 1.03-1.11; p = 0.01), bilateral LTx (OR. 1.71; 95% CI, 1.25-2.34; p = 0.001), and hospitalizations for infections (OR, 1.40; 95% CI, 1.27-1.54; Dinaciclib mouse p < 0.001) and for rejection (OR, 0.55; 95% CI, 0.48-0.65; p < 0.001).

CONCLUSIONS: Examination of a cohort of long-term LTx survivors in the UNOS data set indicates that bilateral LTx and fewer hospitalizations for rejection may portend improved long-term survival after LTx. J Heart Lung Transplant 2010;29:240-6 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.”
“Background: To evaluate vision-related and health-related quality of life (VRQoL, HRQoL) in first stroke patients

with homonymous visual field defects (VFD) with respect to the extent of the lesion. Since VFD occur in approximately 10% of stroke patients the main purpose of the study was to investigate the additional impact of VFD in stroke patients hypothesizing that VFD causes diminished VRQoL.

Methods: In 177 first stroke patients with persisting VFD 2.5 years after posterior-parietal lesions VRQoL was assessed by the National-Eye-Institute-Visual-Functioning-Questionnaire (NEI-VFQ) and HRQoL by the Medical-Outcome-Study Short-Form-36 Health-Survey (SF-36). Questionnaire results of VFD-patients were compared with age-and sex-matched healthy controls and with general non-selected stroke samples as published elsewhere. VFD-type and visual acuity were partially correlated with questionnaire results.