The predominant SW aspect of the enigmatic dragonblood tree underlines the importance of fog. Long-term weather observations by Socotri put these short-term meteorological observations into a longer perspective. Socotri informants also described the Selleckchem Prexasertib drought years when livestock populations crashed, after which windows of opportunities for the regeneration of dragonblood and other grazing-sensitive trees may have occurred. (C) 2010 Elsevier Ltd. All rights reserved.”
“In the current health care climate, economic and cultural conditions have created an

optimal opportunity to envision a new direction for nursing as a profession. Nurses find themselves at the formative stages of charting this new direction. The articulation of a professional practice model provides a framework for setting this new direction and thus the achievement of exemplary clinical outcomes. In this article, the authors describe the evolution of the professional

Tariquidar practice model at the Massachusetts General Hospital and how the model continues to be evaluated and modified over time by the nurses within the system.”
“Epilepsy remains a major medical problem for which there is no effective treatment. Oxidative damage plays an important role in epilepsy pathogenesis and may represent a target for treatment of epilepsy. Recent studies have suggested that nuclear factor learn more erythroid 2-related factor 2 (Nrf2) binds to antioxidant response element (ARE) to induce antioxidant and phase II detoxification enzymes under conditions of oxidative stress, which reduces oxidative damage and accumulation of toxic metabolites. This study evaluated the role of Nrf2-ARE signal pathway in protecting the brain from seizure-mediated damage. Wistar rats and Nrf2-deficient or control mice were chronic kindled in the amygdala. Sulforaphane (SF) was used to activate Nrf2-ARE signal pathway. The progression of kindling, the cognitive impairment and oxidative stress parameters were assessed to determine the extent of seizure-mediated

brain damage. Our results indicate that activation Nrf2-ARE signal pathway with SF in hippocampus suppressed the progression of amygdala kindling, and also ameliorated the cognitive impairment and oxidative stress induced by epileptic seizure. These observations suggest that Nrf2-ARE signal pathway may represent a strategic target for epilepsy therapies. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.”
“Background: Surrogate decision makers (SDMs) face difficult decisions at end of life (EOL) for decisionally incapacitated intensive care unit (ICU) patients. Purpose: To identify and describe the underlying psychological processes of surrogate decision making for adults at EOL in the ICU. Methods: Qualitative case study design using a cognitive task analysis interviewing approach.