Lipid microspheres (LM) were target-drug delivery carriers which

Lipid microspheres (LM) were target-drug delivery carriers which could congregate SGC-CBP30 nmr selectively in the site such as inflammation or injuring blood vessel and change the distribution of drugs in vivo [13, 14]. Flurbiprofen axetil injection, 0.2 μm in diameter, was composed of lipid microspheres

and flurbiprofen axetil[15]. It was target-congregated easily to tumor, especially malignant tumor for there had abundant learn more fresh capillary vessel and released inflammatory factor. The latter could enlarge the fissure of endothelium cells and let it be taken up by macrophages and neutrophils. So, the biosynthesis of prostaglandin was restrained, and the analgesic effects of flurbiprofen axetil would be appeared [16]. Flurbiprofen axetil injection always had better analgesic effects in bone metastasis of tumor while nociceptor pain was mainly expressed [9]. Anaesthetic anodynes were always used in moderate and severe pain patients. It acted in central nerve system, and the analgesic effects was not relative with the site or kind of pain. But, side effects always happened,

such as constipation, breath inhibition, drug dependence, even exciting central nerve system when it was used for long time [2]. Flurbiprofen axetil and other NSAIDs drugs acted in the site of distal nerve. Its analgesic effects were always not bad than anaesthetic anodynes when the inflammatory medium was liberated in the site of muscle, tendon, ligament, and bone. It could be used as first line anodyne and combined with anaesthetic anodynes in corresponding cancer pain [4]. Our results showed that see more intravenous flurbiprofen axetil had better analgesic effect to cancer pain with bone or vertebra metastasis. It could reduce the dosage of the anaesthetic drugs, or increase Leukocyte receptor tyrosine kinase the analgesic effects with little side effect, especially in patient who had constipation or had a tendency of ileus. Our results showed the analgesic effect was better than the Ou Yang’s report [9], and

similar to the report by Xu et al [17]. Perhaps for the reason of insufficient cases, we found that flurbiprofen axetil had slight analgesic effect to cancer pain in abdomen. The half-life time of flurbiprofen axetil was 5.8 hours. Its onset of action was about 15 minutes after being used, and continued about 3 hours in post-operation. When it was used in cancer patients, it began to work quickly about in 30 minutes, and the duration of action was about 9 hours [18]. So it was especially suitable for breakthrough pain to the patient who were using anaesthetic anodyne. We found that most patients could obtain analgesic effects after being added flurbiprofen axetil 50 mg while their pain could not be controlled by anaesthetic drugs. But in some patients, the analgesic effect was only maintained 3–4 hours.

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