Larger studies are warranted to confirm our findings and prevent this feared surgical complication. (J Vase Surg 2011; 54:699-705.)”
“Inadequate beta-cell mass can lead to insulin insufficiency and diabetes. During times of prolonged metabolic demand for insulin, the endocrine pancreas can respond by increasing beta-cell mass, both
by increasing cell size and by changing the balance between beta-cell learn more proliferation and apoptosis. In this paper, we review recent advances in our understanding of the mechanisms that control the adaptive expansion of beta-cell mass, focusing on the islet’s response to pregnancy, a physiological state of insulin resistance. Functional characterization of factors controlling both beta-cell proliferation and survival might not only lead to the development of successful therapeutic strategies to enhance the response of the beta-cell to increased metabolic loads, but also improve islet transplantation regimens.”
“BACKGROUND: After thoracolumbar corpectomy, standard anterolateral instrumentation
may consist of dual rods with cross-connectors. However, when the vertebral bodies are small or involved with disease, only 1 rod may be possible.
OBJECTIVE: To compare the biomechanics of an in vitro L1 corpectomy model using 1 rod, 2 rods, or 2 rods with 2 cross-connectors.
METHODS: Eight fresh frozen human cadaveric spines were potted GNS-1480 purchase from T9 to L3. Pure moments of 1.5, 3, and 4.5 Nm were applied, and the motion of the spine was measured using 3 infrared cameras. Loads were applied in flexion and extension, right and left lateral bending, and right and left axial rotation. Each spine was first tested in the intact state. After performing
an L1 corpectomy and replacement with a carbon fiber reinforced polymer cage, 3 constructs were tested: single rod (1R), dual rod (2R), and dual rod with 2 transverse connectors (CC).
RESULTS: Analysis of variance suggests significant main effects of load (P < .0001), axis (P = .022), construct Farnesyltransferase (P = .0019), and individual spine (P < .0001). Overall, the single-rod construct is significantly less rigid than the intact spine in axial rotation. There is no significant difference between the intact spine and either the dual-rod construct or the dual-rod cross-connector construct.
CONCLUSION: In our in vitro model of anterior spinal stabilization after corpectomy and grafting, a single-rod construct is significantly less rigid than the intact spine. Addition of a second rod returns the rigidity of the spine to the intact state. A dual-rod cross-connector construct is significantly more rigid than a single-rod construct.”
“Background. Improving patient safety has become a national priority. Patient safety indicators (PSIs) are validated tools to identify potentially preventable adverse events. No studies currently exist for evaluating lower extremity (LE) vascular procedures and the occurrence of PSIs.