KOOS knee survey Stanford exercise scales No significant differences selleck chem Trichostatin A were seen between the study groups for either the KOOS survey or the Stanford exer cise scale. Use of analgesics and NSAIDs Review of the clinical report forms showed that no sub ject in either study cohort consumed any of the 43 prohibited medicines or supplements during the study. Safety assessments A total of eight adverse events, equally Inhibitors,Modulators,Libraries dispersed be tween both groups, were noted. None of the adverse events was considered to be associated with UC II supplementation. All events resolved spontaneously without the need for further intervention. No subject withdrew from the study due to an adverse event. Fi nally, no differences were observed in vital signs after seventeen weeks of Inhibitors,Modulators,Libraries supplementation, and no serious ad verse events were reported in this study.

Discussion In this study, the UC II supplement, consisting of undenatured type II collagen, was investigated for its ability to improve joint function in healthy subjects who develop joint pain while undergoing strenuous exercise. The rationale behind Inhibitors,Modulators,Libraries this approach centered on the hy pothesis that strenuous exercise might uncover transient joint changes due to daily physical activities that are not attributable to a diagnosable disease. In the same way that nominally elevated blood levels of lipids, glucose plus high blood pressure and obesity can be predictive of future progression to diabetes and heart disease, the development of joint pain upon strenuous exercise may Inhibitors,Modulators,Libraries be indicative of possible future joint problems.

At study conclusion, we found that subjects ingesting the UC II supplement experienced a significantly greater forward ROM in their knees versus baseline and placebo as measured by knee extension goniometry. Knee exten sion is necessary for daily Inhibitors,Modulators,Libraries function and sport activities. Loss of knee extension has been shown to negatively im pact the function of the lower extremity. For ex ample, loss of knee extension can cause altered gait patterns affecting ankles and the hip which could result in difficulty with running and jumping. Studies have further shown that a permanent loss of 3 5o of ex tension can significantly impact patient satisfaction and the development of early arthritis. By contrast, when knee flexion, another measure of knee function, was assessed via goniometry, no differences in clinical outcomes were observed between the two study co horts.

From a structure function perspective this outcome is not dilution calculator surprising. During the earliest characterized phases of OA there is an apparent preferential loss of knee exten sion over knee flexion, and this loss has been shown to cor relate with WOMAC pain scores. In addition, MRI imaging of the early osteoarthritic knee has shown that ini tial changes in knee structure appear to center on articular cartilage erosions about the patella and other weight bearing regions of the knee.