Further study is needed to clarify the long term impacts of ADMA elevation in CIN patients on future of organ damage. LEE YU JI, CHO SEONG, KIM SUNG ROK Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon Introduction: Although colistin has recently reintroduced as a therapeutic agent for the treatment

of multidrug-resistant organisms, concerns about nephrotoxicity associated with colistin allow the limited use of colistin. The objective of this study was to evaluate the association between colistin doses and the development of nephrotoxicity. Methods: A retrospective cohort study of all patients received intravenous colistin to treat infections caused by multidrug-resistant Gram-negative rods at Samsung Changwon buy LBH589 Hospital was conducted. From INCB024360 clinical trial 2010 to 2013, adult patients receiving colistin for 72 hr or longer were included in this study. The patients with a glomerular filtration rate <50 ml/min/1.73 m2 at baseline were excluded. Nephrotoxicity was defined as doubling of baseline serum creatinine. Colistin dosing was evaluated based on both actual body weight (ABW) and ideal body weight (IBW). Results: One hundred fifty-six patients met inclusion criteria and were included in the analysis. The mean age of the patients was 64.2 ± 15.2 years. Seventy-five patients (48.1%) experienced nephrotoxicity during colistin treatment. The mean onset time of

nephrotoxicity was 10.2 ± 6.3 days. The mean daily dose of colistin based on IBW and ABW was 4.8 ± 1.5 and 5.0 ± 1.6 mg/kg/day, respectively. In logistic regression analysis using backward stepwise selection method to identify predictors of nephrotoxicity, daily colistin dose based on ABW (mg/kg/day) [Odds Ratio (OR) = 1.28, 95% confidence interval (CI), 1.03–1.58] was associated with the development next of nephrotoxicity with concominant use of diuretics (OR = 2.21, 95% CI 1.099–4.458) and serum albumin level (OR = 0.27, 95% CI, 0.11–0.68) after adjusting for concominant uses of inotropics and glycopeptides, age and hematocrit.

However, when colistin dose based on IBW instead of ABW was added in logistic model, colistin dose was no longer a risk factor of nephrotoxicity. Conclusion: Colistin doses based on IBW was not associated with the development of nephrotoxicity during colistin treatment. Colistin dosing based on IBW may be relatively safe from colistin-associated nephrotoxicity. PARAPIBOON WATANYU, SATHITTRAKOOL SUPHASIT, TAWEESAK PANAWAN, CHOEIKAMHAENG LADDAPORN Department of Medicine, Maharat Nakhonratchasima Hospital Introduction: Intermittent hemodialysis (IHD) and Continuous renal replacement therapy (CRRT) have been widely used in acute kidney injury (AKI). However, acute peritoneal dialysis (APD) is still commonly used in AKI especially in hemodynamically unstable patients and unavailable IHD or CRRT. Therefore, outcomes of IHD and APD in treatment of AKI patients need to be clarified.