For items 4 (dish),

6 (jar), and 9 (potato) a strong right-hander would answer left. These three items should therefore be reverse scored by changing the sign on the values given previously (i.e., +1 = Always left, etc.). Having done this, then one can obtain the overall laterality score, an average of all 11 items.” The score was then transformed into percentage (−100% indicating strongly Inhibitors,research,lifescience,medical left-handed and +100%, strongly right-handed). The statistical analysis was conducted as follows. For the tube task, the reach and grasp drawer task, and the bimanual Brinkman board task, we used a binomial test (SPSS®; see Fig. 7). For the scores of the modified Brinkman board task, we used inhibitor purchase either the paired t-test or the Wilcoxon signed-rank test (Sigmastat®). Finally, for the CT derived from the modified Brinkman board task, we used either the unpaired t-test or the Mann–Whitney U test (Sigmastat®). Figure 7 Hand preference analysis for monkeys and human subjects. Inhibitors,research,lifescience,medical In panel (A), the bar graph displays the handedness index (HI) for the bimanual Brinkman board and the tube tasks in human subjects and for Inhibitors,research,lifescience,medical the bimanual Brinkman board, the tube and the reach and … In order to limit the duration of the behavioral session with human subjects to a reasonable

extent, the modified Brinkman board task using both hands simultaneously, as well as the reach and grasp drawer task, were not performed Inhibitors,research,lifescience,medical with human subjects. These tests, aimed in the monkeys to determine their preferred hand, were considered redundant for human subjects with the handedness questionnaire. Results Hand dominance: unimanual modified Brinkman board task Monkeys For monkeys, the hand Regorafenib CAS dominance was determined based on the total score in 30 sec (sum of vertical and horizontal slots in all behavioral sessions) and the CT (measured for the first five horizontal and the first five vertical slots) in the 20 last recorded sessions of the modified

Brinkman board task, at plateau. The performance of one hand was compared to the performance of the other hand, measured in the two consecutive unimanual Inhibitors,research,lifescience,medical tests carried out on the same day. The dominant hand is the hand exhibiting a higher score, respectively, a shorter Batimastat CT, than the opposite hand. For this specific analysis of hand dominance, only the score at plateau was taken into consideration (see Fig. ​Fig.2A).2A). A typical example of the score data is illustrated for one monkey (Mk-AT: left and right hand for total, vertical and horizontal slots) in Figure ​Figure2A,2A, with a vertical dashed line separating the plateau phase from the preceding learning phase. Figure 2 Hand dominance analysis for monkeys. An example of scores (Mk-AT) for the left and the right hand when the use of the hand was imposed in the modified Brinkman board task is shown in panel (A). Along the abscissa, the values refer to the consecutive daily …