Clinical abnormalities range from ultrasound report of fatty liver (NAFLD) to elevated transaminases (NASH), or even cirrhosis and liver cancer. Z-VAD-FMK in vivo Pathogenic mechanisms include inflammatory reactions induced by cytokine and adipokine activation and oxidative stress. Antioxidant supplements, therefore, could potentially protect cellular structures against oxidative stress.
This study aims to review and analyze the potential role of Vitamin E as an anti-oxidant in patients with NASH. Methods: A systematic search for randomized controlled trials through Google Scholar, Cochrane review, GastroHep and Pubmed data, supplemented by a manual search for other relevant journals was conducted. Metaanalysis of these articles was done. Results: Randomized controlled trials (n = 424 patients) using Vitamin E in the treatment TSA HDAC of NASH, the outcome being shown as decrease in the levels of liver transaminases, showed no significant effects compared to placebo. Conclusion: There was no benefit of Vitamin E therapy in the treatment of NASH based
on the primary outcome of decreased and or normalization of transaminases as the primary outcome in this meta-analysis. Key Word(s): 1. NAFLD; 2. SGPT, SGOT; 3. Vitamin E; Presenting Author: ERICKSON TENORIO, MD TENORIO Additional Authors: HIGINIO MAPPALA, MD, FPCP, FPSG, FPSDE MAPPALA Corresponding Author: ERICKSON
TENORIO, MD TENORIO Affiliations: Philippine Society of Gastroenterology Objective: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in adults worldwide. It is an increasingly recognized condition that may progress to end stage liver disease, cirrhosis or liver cancer. Multiple hypotheses have been postulated in its pathogenesis and several therapeutic options have been offered, ranging 上海皓元 from treatment of associated metabolic conditions such as diabetes and hyperlipidemia, improving insulin resistance by weight loss, exercise and or pharmacotherapy and use of hepatoprotective agents. Bile Acids, like Ursodeoxycholic acid (UDCA) has also been shown to be effective in some studies. This study aims to evaluate the efficacy of High-dose UDCA (URSOLIV, at 30 mg/KBW) to that of standard (Std-UDCA at 15 mg/KBW). Methods: A systematic search of all randomized controlled studies thru Google, Medline, Trip base, Wiley, GastroHep and PubMed database for the National Library of Medicine, supplemented by a manual search of other relevant journals was conducted using the terms NAFLD and UDCA. There were 22 potentially related papers found. Metaanalysis was done on these papers based on our inclusion criteria.