All authors state that they have no conflicts of interest The wo

All authors state that they have no conflicts of interest. The work was performed at MRC Human

Nutrition Research, Cambridge, UK and MRC Keneba, The Gambia and supported by the UK Medical Research Council [Unit Programme numbers U105960371 and U123261351]. We should like to thank the clinical, scientific and field staff at MRC Keneba; the scientists and lab staff at MRC HNR, and Dr Mato Nagel from the Laboratory for Molecular Diagnostics, Centre of Nephrology and Metabolic Disorders, Berlin, for conducting the genetic analyses. “
“In the author line, the name of Stutee Khandelwal was spelled incorrectly. The correct author line appears above. “
“In the author line, the name of Stutee Khandelwal was spelled incorrectly. The correct author line appears above. “
“M. Nerlander has been re-instated SB203580 nmr as an author. The correct author line appears above. Also the Acknowledgment is changed Tacrolimus concentration to remove the mention of M. Nerlander as he has been re-instated as an author. The rest of the Acknowledgment remains unchanged. “
“The Acknowledgements

section has been updated to include corrected grant information. The correct acknowledgements appear below. The NIAMS and NIDCR supported this work (R01 AR048147, R01 DE020194, T32 AR056950, F32 AR60140, F32 AR61873). The authors thank David Razidlo and Bridget Stensgard for mouse colony maintenance, the Mayo Clinic Summer Undergraduate Research Fellowship program for funding, and the Mayo Clinic Biomaterials and Quantitative Histomorphometry Teicoplanin Core Laboratory for assistance with histological specimen preparation. “
“Rett syndrome (RTT), traditionally considered a neurodevelopmental disorder, mainly affects girls and is due principally to mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2) [1] and [2]. The age of onset is typically around 6–18 months after birth with characteristic symptoms including loss of speech, reduced head growth, stereotypic hand movements, motor dysfunction

and autism-like features [2]. Whilst it is well established that the majority (> 95%) of classical RTT cases are due to mutations in the MECP2 gene, the underlying function and regulation of MeCP2 protein remains unclear [3], [4], [5] and [6]. MeCP2 is a nuclear protein and is especially abundant in the brain. However, it is also expressed throughout the body [7], [8] and [9] and in addition to the neurological phenotypes, a number of overt peripheral phenotypes are also common in RTT. For instance, spinal deformity (principally scoliosis and excessive kyphosis) is a very common feature, with ~ 50–90% of patients developing severe scoliosis [10], [11] and [12], many of whom require corrective surgery. Other prominent skeletal anomalies include early osteoporosis, osteopenia, bone fractures and hip deformities [13], [14], [15], [16] and [17]. Previous studies have found that Rett syndrome patients have reduced bone mass [18], [19], [20] and [21].

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>