Activation of TRPM8 ion channel changes the effect of subsequent PD98059 temperature exposure-cooling or heating. Preliminary application of menthol eliminates the inhibitory effect of deep cooling on immune response. Stimulation of the antigen binding in spleen at deep heating is inversed to suppression in case of heating on the background of TRPM8 activation by menthol.
On the contrary, suppression of antibody formation caused by deep heating is eliminated if heating is carried out on the background of TRPM8 stimulation.
It can be suggested that a significant influence of TRPM8 agonist menthol on the immune response is mainly related to changes in signal of the skin temperature afferent nerve fibers where TRPM8 ion channel is expressed. (C) 2012 GS-9973 Elsevier Ltd. All rights reserved.”
“The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated recovered depressed patients
and healthy controls.
This study aims to assess brain 5-HTT binding in a group of unmedicated acutely depressed patients in comparison to healthy controls.
We studied 5-HTT binding using [C-11]DASB in conjunction with positron emission tomography in 12 medication-free depressed patients with a mean duration of illness of about 1 year and 24 healthy controls.
The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex.
These selleck chemicals llc results
suggest that diminished availability of the 5-HTT in the brain may be a state marker of acute depression. Alternatively, low 5-HTT binding may delineate a group of depressed patients with a poor long-term prognosis.”
“In terms of total number of publications, the laboratory mouse (Mus musculus) has emerged as the most popular test subject in biomedical research. Mice are used as models to study obesity, diabetes, CNS diseases and variety of other pathologies. Mice are classified as homeotherms and regulate their core temperature over a relatively wide range of ambient temperatures. However, researchers find that the thermoregulatory system of mice is easily affected by drugs, chemicals, and a variety of pathological conditions, effects that can be exacerbated by changes in ambient temperature. To this end, a thorough review of the thermal physiology of mice, including their sensitivity and regulatory limits to changes in ambient temperature is the primary focus of this review. Specifically, the zone of thermoneutrality for metabolic rate and how it corresponds to that for growth, reproduction, development, thermal comfort, and many other variables is covered.