8 mm (A). The peak velocity across the narrowed DNA Synthesis activity inhibition orifice measured more than … Discussion The LAA ostial stenosis is a very rare finding that is generally detected incidentally

on transesophageal echocardiography. LAA ostial stenosis can be classified into 2 categories: one is the LAA with a congenitally narrowed orifice and the other is a remnant LAA after incomplete LAA ligation, which is conducted during open cardiac surgery. According to a previous report that analyzed 500 autopsy cases, the size of the normal LAA Inhibitors,research,lifescience,medical orifice ranges from 6 mm to 20 mm in men and from 5 mm to 18 mm in women. Thus, the size of a LAA orifice less than 5 mm could be sufficient for the diagnosis of LAA ostial stenosis.1) Inhibitors,research,lifescience,medical In our cases, the LAA orifice measured between 3.8 to 4.8 mm, and significant flow acceleration across the orifice was observed as well. Our patient of the second

case had a history of cardiac surgery 16 years ago. The patient’s operation record was not found, so it was not clear whether the narrowed orifice of the LAA was idiopathic LAA ostial stenosis or a postoperative complication. However, the patient’s electrocardiography showed normal sinus rhythm before the coronary artery bypass surgery, and the preoperative transthoracic echocardiography revealed the normal structure of the Inhibitors,research,lifescience,medical mitral valve, and there was no significant enlargement of the left atrium. On discharge summary note, only 1 operation name was written. In addition, the LAA exclusion operation was not routinely performed in our hospital at Inhibitors,research,lifescience,medical that time unless the patient was on the Maze operation. Thus, it is plausible to consider our patient’s findings as idiopathic LAA ostial stenosis rather than an incompletely ligated LAA. Furthermore, the transesophageal echocardiographic findings were similar for both

patients. Since there have been few case reports of this malady, the incidence, pathophysiology and clinical implications of idiopathic LAA ostial stenosis are unclear. In a previous report, the possibility Inhibitors,research,lifescience,medical was suggested that the relative blood stagnation behind the stenotic area could increase the risk of thrombus formation in the LAA.2) In another report, the accelerated flow across the stenotic area was assumed to have injured the endocardial tissue and this resulted in endocarditis.3) However, these reports failed to show direct associations Selleck Torkinib with the patients’ clinical events. On the other hand, there have been a relatively larger number of cases on LAA ostial stenosis after incomplete surgical ligation. An incompletely ligated LAA is known to have similar echocardiographic findings as those observed for idiopathic LAA ostial stenosis, including the LAA morphology, the narrowed LAA orifice and the accelerated blood flow across the stenotic area.