1 ± 10.4 years and 62.9% were male. A total of 2,277 subjects (68.9%) had diastolic cardiac dysfunction; 1,843 were grade 1 and 434 were grade 2. More advanced diastolic dysfunction (normal, grade 1, grade 2) was associated with higher prevalence of NAFLD (OR, 2.15; 95% CI, 1.87-2.47; P<0.001). On multivariate analysis, the presence NAFLD was significantly associated with both the presence of diastolic dysfunction (odds ratio [OR], 2.02; 95% confidence interval [CI], 1.65-2.49; P<0.001) and the increased diastolic dysfunction www.selleckchem.com/products/Trichostatin-A.html grades (normal, grade 1, grade 2) (OR, 1.63; 95% CI, 1.39-1.91; P<0.001) after adjustment for age, sex, hypertension, body mass index, and serum levels

of cholesterol and triglycerides. More advanced diastolic dysfunction (normal, grade 1, grade 2) was associated with higher prevalence of NAFLD (OR, 2.15; 95% CI, 1.87-2.47; P<0.001). CONCLUSIONS: Patients with NAFLD have an increased risk for diastolic cardiac dysfunction independent of classical risk factors. Disclosures: The following people have nothing to disclose: Jeong-Hoon Lee, Donghee Kim, Goh Eun Chung, Min-Sun Kwak, Yoon Jun Kim, Jung-Hwan Yoon, Hyo-Suk Lee Background and Aims: The prevalence of non-alcoholic fatty liver Disease (NAFLD) is increasing in parallel to the epidemics

of obesity and diabetes. Although histological differences have been reported between pediatric and adult NAFLD, potential age related changes in serum transaminases 上海皓元 LY294002 in vivo and liver histology remain largely unexplored. Therefore, the aim of our study was to investigate the clinical and histological characteristics of NAFLD across different age groups of adults. Methods: This was a cross sectional study of

502 biopsy proven NAFLD patients recruited from two hepatology outpatient clinics in Cleveland. Clinical data including demographics, anthropometry, medical history, biochemical and liver biopsy findings were evaluated. Comparisons of clinical characteristics and histologic changes were made among different age groups; group A(aged 18 to 44), B(aged 45 to 64) and C(aged 65 and over). Results: In this cohort of NAFLD patients, 34.9%, 56.0% and 9.1% of the cohort were distributed among group A, B, and C respectively. While the prevalence of non-alcoholic steatohepatitis (NASH) was comparable across age groups, the prevalence of advanced fibrosis increased with age; 17.7%, 31.1% and 50.0% of groups A, B and C respectively (p=0.000). Mean ALT progressively decreased with age; 87, 64, 56 U/L in group A, B, and C respectively (p=0.000) with a corresponding increase in the proportion of patients with normal ALT with age (p=0.003). In contrast, there was no difference in mean AST or proportion of patients with normal AST (p=0.939) across age. The AST: ALT ratio (AAR) progressively increased from 0.7 to 0.9 to 1.1 in group A, B and C respectively (p=0.000).