NMDA receptor-independent LTP in stratum oriens interneurons is associated with changes in trial-to-trial variability, paired-pulse ratios, failure rates (Alle et al., 2001; Perez et al., 2001; Lapointe et al., 2004), and susceptibility to a use-dependent blocker of postsynaptic rectifying AMPA receptors (Lamsa et al., 2007b), suggestive of a persistent increase in release probability. The putative retrograde messenger has

not, however, been identified. NMDA receptor-independent LTP occurs at synapses on O-LM, parvalbumin-positive basket, axo-axonic, www.selleckchem.com/products/bmn-673.html and ivy cells, but not on CCK-positive CB1 receptor-expressing basket cells, while synapses on bistratified neurons are persistently depressed by similar induction stimuli (Lamsa et al., 2007b; Nissen et al., 2010; Szabo et al., 2012). Strikingly, LTP is restricted PFT�� to the pathway that was stimulated during the induction protocol, suggesting a role for micron-scale Ca2+ compartmentalization in relatively aspiny dendrites (Goldberg and Yuste, 2005; Castillo and Khodakhah, 2006; Topolnik et al., 2009). Both NMDA receptor-dependent LTP (Figure 3B) and NMDA receptor-independent LTD occur at synapses made by Schaffer collaterals on interneurons in stratum radiatum or stratum pyramidale

(McMahon and Kauer, 1997; Cowan et al., 1998; Wang and Kelly, 2001; Lamsa et al., 2005). These cells have not, in general, been classified systematically and probably include several different types. The induction and expression properties of LTP at Schaffer

collateral synapses are similar in most respects to those of LTP in principal cells (Wang and Kelly, 2001; Lamsa et al., 2005), although CaMKIIβ may play the role of the α isoform (Lamsa et al., 2007a). As for LTD induction, this is insensitive to the postsynaptic membrane potential and independent of NMDA receptors but requires intact group I mGluR and postsynaptic Ca2+ signaling and is accompanied by changes in trial-to-trial Isotretinoin variability suggestive of presynaptic expression (McMahon and Kauer, 1997; Gibson et al., 2008). It has also been reported to spread to nonstimulated synapses. Presynaptic TRPV1 channels have been implicated as receptors for a retrograde factor, mimicked by the endogenous eicosanoid 12-(S)-HPETE (Gibson et al., 2008). However, TRPV1 is not abundant in intrinsic hippocampal neurons (Cavanaugh et al., 2011). Another signaling cascade coexists, leading from postsynaptic mGluR5s to long-lasting depression of glutamate release from Schaffer collaterals independently of either TRPV1 or CB1 receptors (Le Duigou et al., 2011; Edwards et al., 2012). Both LTP and LTD also occur at synapses made by mossy fibers (the axons of dentate granule cells) on dentate basket cells or interneurons in CA3 (Laezza et al., 1999; Alle et al., 2001; Lei et al., 2003; Laezza and Dingledine, 2004; Lei and McBain, 2004; Galván et al., 2008; Sambandan et al., 2010).