The first transatlantic fiber-optic cable connecting the US and UK and allowing 40,000 simultaneous telephone calls was lauded as a communications milestone. The first virus infected the internet, still a largely academic communication medium. The antidepressant Prozac was first introduced to the US market and quickly became one of the top-selling drugs in history. In science, Sir

James W. Black, Gertrude B. Alectinib molecular weight Elion, and George H. Hitchings were awarded the Nobel Prize in Physiology and Medicine for their work on “important principles for drug treatment,” developing new drugs targeted for specific biochemical pathways. Fiscal budgets were tight, the NIH was facing cuts to its operating budget, and the scientific community was worried. And amid all of this, the first issue of Neuron was launched in March of 1988 and contained papers on axon branching, channel biophysics, hippocampal LTP, and molecular analyses of gene expression. A lot has changed in the past 25 years for science and the world, but in many ways, the issues that preoccupied us then, as scientists and world citizens, continue to preoccupy us today. Since its inception, Neuron has find more been positioned as a journal that reaches out broadly to the neuroscience community. In the first issue, the

journal’s founders put forth a vision grounded on the pillars of exciting and innovative science, interdisciplinary thinking, the value of basic mechanistic research, and the catalyzing opportunities afforded by technology. In an Editorial in the first issue, the founding editors wrote, “By bringing together papers using methods ranging from biophysics to advanced structural analysis to molecular genetics, the journal can encourage, educate, and sustain a readership of broad technical literacy that shares an interest in common biological questions.” This core vision holds as true today as it did in 1988. This issue is a celebration of the journal and the developments in the field over the past 25 years. We have brought together a series of essays that build on this vision, reflect on the history of the field, and project forward

to the future. One of the most enjoyable and satisfying aspects of compiling an issue like this (and hopefully this applies to reading it as well) is the chance to step back and reflect. Too often in our world, we are busy Phosphatidylinositol diacylglycerol-lyase looking forward and rarely does one have the chance to admire the full view. In considering topics for this special collection, it was difficult to winnow down the list and capture in full scope the tremendous progress and excitement that we’ve seen in this field over the last few decades. Each Perspective tackles a different subject area in the field, and yet, it is interesting to see some common themes emerge: The importance of interdisciplinary science. The brain is a complex puzzle and no one system or methodology will be sufficient to crack it.