01 Hz, at the level of the sensor attached to the scalp. HIRREM software analytics then identify dominant frequencies in specific spectral brackets, in up to 48,000 bins of spectral data for any given

bracket. Brackets are assigned by the software based on a proprietary algorithm. The software compares the two channels of data to ascertain Inhibitors,research,lifescience,medical the symmetry between channels of EEG information and proportionation of spectral power within the channels. From the bracket of frequencies assigned for the subject’s exercise, the HIRREM software translates the dominant EEG frequency in a given instant of time to an audible musical tone, which is received by the subject through earphones. Depending on algorithm calculations, the delay between measurement and analysis of neural oscillatory activity and consequent presentation of corresponding musical tones can be as narrow as an estimated 12 msec. The process then iterates. The Inhibitors,research,lifescience,medical HIRREM mathematical algorithms to define specifically how and when the dominant EEG frequencies are selected for resonance are informed by relationships among the parameters of the individual’s own unique spectral Inhibitors,research,lifescience,medical EEG. The specific

tone is produced from a proprietary mathematical algorithm principally informed by the dominant frequency within the observed spectral bracket. A sample sequence of tones produced during 1 min of a HIRREM exercise and the corresponding notes on the pentatonic scale are available as Internet resources, in the form of audio, and pdf files. Application of HIRREM exercises to the bilateral temporal lobes is emphasized, as we theorize that comparison of spectral EEG amplitudes in simultaneous Inhibitors,research,lifescience,medical BKM120 recordings at the bilateral

Inhibitors,research,lifescience,medical temporal lobes (T3 and T4 in the 10–20 International EEG system) may provide an opportunity to engage the degree of balance between the sympathetic and parasympathetic divisions of the autonomic nervous system. As noted in Introduction, numerous studies have found that management of the autonomic nervous system is lateralized in the cerebral hemispheres. Specifically, right insular cortex appears to drive sympathetic functioning, whereas left insular Oxalosuccinic acid cortex drives parasympathetic functioning (Craig 2005). T3 and T4 are located over Brodmann areas 21 and 22, respectively, at the middle and superior gyri of the temporal lobes (Homan et al. 1987) and are therefore in the proximity of insular cortex. Apart from a focus on the temporal lobes, HIRREM exercises take place for major regions of the cortex including frontal, parietal, occipital lobes, central strip, and the midline, and across the EEG frequency spectrum in each of those locations. At the conclusion of a single HIRREM session, the provider runs an analysis program which shows summary data for the session.